Blockade of 5-Hydroxytryptamine Antidiuresis in Rats by 2-Bromlysergic Acid Diethylamide Tartrate and 1-Methyl-Lysergic Acid Butanolamide
A Chodera
Journal of Pharmacy and Pharmacology September 1, 1963 DOI: 10.1111/j.2042-7158.1963.tb12802.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | BOL 148 UML 491 5-hydroxytryptamine |
| Dose | 5-HT: 1 mg/kg; BOL 148: 5 mg/kg; UML 491: 2.5 mg/kg |
| Topics | LSD |
| Key findings | BOL 148 and UML 491 counteract 5-HT-induced antidiuresis in rats but do not affect antidiuresis from posterior pituitary extract. |
Abstract
Abstract The effects of two lysergic acid derivatives, 2-bromlysergic acid diethylamide ‘BOL 148’ and 1-methyl-lysergic acid butanolamide ‘UML 491’ on the antidiuresis induced by 5-hydroxytryptamine ‘5-HT’ has been studied in rats given a dose of 1 mg./kg. 5-HT subcutaneously. BOL 148, 5 mg./kg., and UML 491, 2·5 mg./kg., counteracted the induced antidiuresis. By contrast, the antidiuretic effect of posterior pituitary extract was not blocked or diminished by BOL 148 or by UML 491. BOL 148 and UML 491 alone did not have a diuretic or antidiuretic action.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.