Parkinson disease psychosis: from phenomenology to neurobiological mechanisms.
Javier Pagonabarraga, Helena Bejr-Kasem, Saul Martinez-Horta, Jaime Kulisevsky
Nature Reviews Neurology March 1, 2024 DOI: 10.1038/s41582-023-00918-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Philosophy of mind |
| Key findings | Parkinson disease psychosis arises from brain alterations caused by PD itself combined with dopaminergic drug use, involving dysfunction in multiple neural systems. |
Abstract
Parkinson disease (PD) psychosis (PDP) is a spectrum of illusions, hallucinations and delusions that are associated with PD throughout its disease course. Psychotic phenomena can manifest from the earliest stages of PD and might follow a continuum from minor hallucinations to structured hallucinations and delusions. Initially, PDP was considered to be a complication associated with dopaminergic drug use. However, subsequent research has provided evidence that PDP arises from the progression of brain alterations caused by PD itself, coupled with the use of dopaminergic drugs. The combined dysfunction of attentional control systems, sensory processing, limbic structures, the default mode network and thalamocortical connections provides a conceptual framework to explain how new incoming stimuli are incorrectly categorized, and how aberrant hierarchical predictive processing can produce false percepts that intrude into the stream of consciousness. The past decade has seen the publication of new data on the phenomenology and neurobiological basis of PDP from the initial stages of the disease, as well as the neurotransmitter systems involved in PDP initiation and progression. In this Review, we discuss the latest clinical, neuroimaging and neurochemical evidence that could aid early identification of psychotic phenomena in PD and inform the discovery of new therapeutic targets and strategies.
Comparable studies
Other narrative reviews on philosophy of mind, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Body Consciousness: A Philosophy of Mindfulness and Somaesthetics | 2008 | Review article | |
| Phenomenology, Structure, and Dynamic of Psychedelic States | 2016 | Review | |
| Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates. | 2018 | Review | |
| The lived experience of psychosis: a bottom-up review co-written by experts by experience and academics. Individuals with lived experience of psychosis, family members, and carers | 2022 | Co-written bottom-up review | |
| From autopoiesis to neurophenomenology: Francisco Varela's exploration of the biophysics of being. | 2003 | Review |
Citations in the library
Cited by 2
Cites 8
- Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. Pharmacology & Therapeutics May 1, 2019
- Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks? Movement Disorders September 23, 2011
- Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects Frontiers in Behavioral Neuroscience 2011
- Feeling of presence in Parkinson's disease Journal of Neurology Neurosurgery & Psychiatry May 7, 2011
- Understanding visual hallucinations: A new synthesis. Neuroscience & Biobehavioral Reviews July 1, 2023
and 3 more in the library