Iontophoretic release of acetylcholine, noradrenaline, 5‐hydroxytryptamine and d‐lysergic acid diethylamide from micropipettes
British Journal of Pharmacology 1970 DOI: 10.1111/j.1476-5381.1970.tb09913.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro experimental study Peer reviewed |
|---|---|
| Population | Cats (intact and decerebrate) |
| Topics | LSD |
| Citations | 68 |
| Key findings | Iontophoretic release of tested neurotransmitters is directly proportional to electrical charge, with transport numbers varying by micropipette size and compound. |
Abstract
1. The in vitro iontophoretic release of tritium-labelled acetylcholine and 5-hydroxytryptamine from large and small micropipettes and noradrenaline and D-lysergic acid diethylamide from small micropipettes was determined by liquid scintillation counting.2. The release was directly proportional to the electrical charge passed in the range normally used in the iontophoretic study of these compounds. The transport numbers obtained for the large micropipettes were approximately double those with the small micropipettes. A very low transport number was found for D-lysergic acid diethylamide.3. The spontaneous leakage was small and did not vary appreciably with time.4. The iontophoretic release of acetylcholine in vitro agreed with the in vitro measurements.5. The brain-stem tissue concentration of D-lysergic acid diethylamide after intravenous injection into intact and decerebrate cats was determined.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.