The neurophenomenology of basic self-disturbance in early psychosis: Association with clinical outcome in an ultra-high risk sample.
Vera A Barata, Suzie Lavoie, Łukasz Gawęda, Emily Li, Louis Sass, Danny Koren, Patrick D. Mcgorry, Bradley N Jack, Josef Parnas, Andrea Polari, Kelly Allott, Jessica A Hartmann, Marija Krcmar, Andreas R Rasmussen, Thomas J Whitford, Cassandra Mj Wannan, Barnaby Nelson
Australasian Psychiatry August 1, 2025 DOI: 10.1177/10398562251346619 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 43 |
| Population | Ultra-high risk (UHR) individuals |
| Duration | 12-month follow-up |
| Topics | Philosophy of mind |
| Keywords | Neurocognition Prodrome Psychosis Schizophrenia |
| Citations | 3 |
| Key findings | Higher baseline basic self-disturbance scores predicted worse clinical outcomes at 12 months in ultra-high risk individuals. |
Abstract
IntroductionWe previously proposed a neurophenomenological model of schizophrenia, linking basic self-disturbance with neural deficits of source monitoring and aberrant salience. Baseline comparisons in ultra-high risk (UHR) and first-episode psychosis (FEP) samples indicated a relationship between basic self-disturbance and source monitoring deficits, but not aberrant salience. The current paper reports on the 12-month follow-up results in the UHR group (n = 43), focusing on the association between baseline variables and clinical outcomes.MethodsOne-way ANOVA compared UHR-remitters (n = 18), UHR-persistent/transitioned to psychosis cases (n = 25) and FEP (n = 38) groups on baseline clinical and neuro-measures. Logistic regression assessed the baseline variables' predictive power for UHR outcomes.ResultsHigher baseline self-disturbance scores (EASE total) were found in the UHR persistence/transition and FEP groups compared to the UHR-remission group, and predicted worse UHR clinical outcomes. Source monitoring deficits were higher in FEP individuals compared to those with UHR persistence/transition.ConclusionHigh levels of basic self-disturbance may be a useful predictor marker of poor prognosis in UHR patients.
Comparable studies
Other observational and cohort studies on philosophy of mind, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The phenomenology of near-death experiences Subjects who reported near-death experiences | 1980 | Retrospective study | n = 78 |
| Visual Phenomenology of the LSD Flashback Persons with a history of LSD use | 1983 | Observational cohort | n = 123 |
| The neurophenomenology of neutral hypnosis. Individuals of high, medium, and low hypnotizability | 2013 | Observational cohort | n = 37 |
| The Phenomenology of Acute Organic Psychosis Patients with acute organic psychosis and acute schizophrenics | 1987 | Observational cohort | n = 148 |
| EEG oscillatory states as neuro-phenomenology of consciousness as revealed from patients in vegetative and minimally conscious states. Brain-damaged patients with disorders of consciousness and healthy-conscious subjects | 2012 | Observational cohort |
Citations in the library
Cites 9
- Self‐experience in the early phases of schizophrenia: 5‐year follow‐up of the Copenhagen Prodromal Study World Psychiatry October 1, 2011
- The neurophenomenology of early psychosis: An integrative empirical study. Consciousness and Cognition November 1, 2019
- From Self-Disorders to Ego Disorders Psychopathology 2015
- Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia Current Problems of Psychiatry September 1, 2017
- The phenomenological nature of schizophrenia and disorder of selfhood. Schizophrenia Research August 1, 2024
and 4 more in the library