The Mechanisms and Effects of Psychedelics

Psychedelics produce profound changes in consciousness, including ego dissolution and enhanced sensory perception, and are medically safe for most people. Repeated use leads to tachyphylaxis, which prevents biological dependence. MDMA has greater abuse potential and less tachyphylaxis than LSD or psilocybin. Psychedelics activate 5-HT2B receptors, which is linked to heart valve disease, posing a theoretical risk with microdosing.

Study at a glance

Abstract

Psychedelics generally elicit a profound change in consciousness, often with ego dissolution, mystical experiences, and enriched sensory perception, but are medically safe for most. Tachyphylaxis occurs after repeated psychedelic administration, preventing biological dependence. MDMA may have some abuse potential and less tachyphylaxis compared to LSD/psilocybin. Psychedelics have 5-HT2B agonist activity associated with cardiac valvulopathy, presenting a theoretical risk with microdosing.