A Report of Nausea and Vomiting with Discontinuation of Chronic Use of Salvia divinorum
C. R. Travis, G. A. Ray, K. F. Marlowe
Case Reports in Medicine August 22, 2015 DOI: 10.1155/2012/543747 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 51-year-old Caucasian woman |
| Duration | 3–4 months of daily use, 48-hour withdrawal period before symptoms, 1-day hospitalization |
| Topics | Salvia divinorum |
| Citations | 12 |
| Key findings | A 51-year-old woman possibly developed gastrointestinal manifestations suggestive of withdrawal from Salvia divinorum after smoking the substance consistently for 3 to 4 months. |
Abstract
Introduction. This is the first reported case of gastrointestinal symptoms associated with withdrawal after chronic use of this substance. Case Presentation. A 51-year-old Caucasian woman was referred to a hospital with a 3-day history of nausea, vomiting, diarrhea, and abdominal discomfort. She reported no sick family members or contact with anyone who was ill. She did report smoking 3–5 cigarettes of the herb “Salvia” consistently for 3-4 months and quit approximately 48 hours before symptoms appeared. Her use of the herb had been consistent; she smoked several cigarettes each day. Laboratory results were essentially normal including the white blood cell count. She received symptomatic treatment and was released after one day. Discussion. Salvinorin A, a kappa-opioid receptor agonist, is the major active ingredient of S. divinorum. The unique opioid properties of this herb may explain its ability to cause changes in intestinal transit time. Conclusion. A 51-year-old woman possibly developed gastrointestinal manifestations suggestive of withdrawal from Salvia divinorum after smoking the substance consistently for 3 to 4 months. The widespread use of this herb will make the potential for withdrawal syndromes more commonplace.
Comparable studies
Other case reports and case series on salvia divinorum, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Salvia divinorum: an hallucinogenic mint which might become a new recreational drug in Switzerland. Salvia divinorum specimens seized in Switzerland | 2000 | Case study | |
| Antidepressant Effects of the Herb Salvia Divinorum: A Case Report 26-year-old woman with history of depression | 2001 | Case study | n = 1 |
| Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification-Salvinorin A as a case study. | 2016 | Database construction with computational prediction and case study | |
| Prolonged hallucinations and dissociative self mutilation following use ofSalvia divinorumin a bipolar adolescent girl A 17-year-old girl with bipolar disorder | 2010 | Case study | n = 1 |
| Case series: Salvia divinorum as a potential addictive hallucinogen. Patients presenting with an enduring and pervasive pattern of salvia use | 2018 | Case study | n = 2 |
Citations in the library
Cited by 7
- A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics. Phytochemistry May 1, 2017
- Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects Pharmaceuticals February 3, 2021
- The subjective experience of acute, experimentally-induced Salvia divinorum inebriation. Journal of Psychopharmacology April 1, 2015
- Salvia divinorum: from Mazatec medicinal and hallucinogenic plant to emerging recreational drug. Human Psychopharmacology: Clinical and Experimental September 1, 2013
- Salvinorin A content in legal high products of Salvia divinorum sold in Mexico. Forensic Science International April 1, 2015
and 2 more in the library
Cites 10
- Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences September 3, 2002
- Opioid receptors and legal highs:Salvia divinorumand Kratom Clinical Toxicology 2008
- Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug and Alcohol Dependence November 8, 2006
- Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum. Drug and Alcohol Dependence May 1, 2011
- Evaluation of herbal dietary supplements marketed on the internet for recreational use. Annals of Pharmacotherapy October 1, 2005
and 5 more in the library