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[Altered states of consciousness induced by N,N-dimethyltryptamine (DMT)].

P Bickel, A Dittrich, J Schoepf

Pharmakopsychiatrie, Neuro-Psychopharmakologie September 1, 1976 DOI: 10.1055/s-0028-1094495 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Sample size 38
Population Volunteers
Interventions N N-Dimethyltryptamine (DMT)
Dose 250 mcg/kg
Topics 5-MeO-DMT Altered states of consciousness DMT
Citations 12
Key findings A low dose of DMT (250 mcg/kg) produced significant differences from placebo across multiple altered states of consciousness syndromes and somatic side effects.

Abstract

In a controlled study on 38 volunteers the effects of 250 mcg/kg N,N-Dimethyltryptamine (DMT) i.m. were assessed. 26 subjects received DMT and 12 placebo. The altered states of consciousness and the somatic changes were measured by several questionnaires administered after the experiment. In spite of the low dose as compared to previous studies significant differences to placebo were found in the following syndromes of altered states of consciousness: visual hallucinations rep. illusions, impairment of memory and attention, changes of body image, depersonalization syndrome, derealization syndrome, euphoric state, anxious-depressive state and delusion. The somatic side effects were mainly subjective respiratory troubles, dizziness and weakness.

Comparable studies

Other randomized controlled trials on 5-MeO-DMT, most cited first.

Study Year Design Participants
Dose-Response Study of N,N-Dimethyltryptamine in Humans Experienced hallucinogen users 1994 Double-blind, saline placebo-controlled, randomized study n = 12
Psychological Effects of (S)-Ketamine and N,N-Dimethyltryptamine (DMT): A Double-Blind, Cross-Over Study in Healthy Volunteers Healthy volunteers 2005 Double-blind crossover study n = 9
Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans Experienced hallucinogen users 1996 Randomized controlled trial n = 13
Pharmacokinetics of N,N-dimethyltryptamine in Humans. Healthy adults 2023 Phase I component of a phase I/IIa randomised, double-blind, placebo-controlled, parallel-group, dose-escalation trial n = 24
Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis Healthy volunteers 2007 Double-blind crossover study n = 15

Citations in the library

Cited by 4

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5-MeO-DMT Altered states of consciousness DMT Depression Philosophy of mind