Ex Vivo Effect of Ibogaine on the Transcriptional Level of Antioxidant Defense Related Genes in Honey Bee (Apis mellifera, L.) Midgut
Elvira Vukašinović, Jelena Purać, Danijela Kojić, Tatjana Čelić, Ivan Pihler, Duško Blagojević
Brazilian Archives of Biology and Technology 2021 DOI: 10.1590/1678-4324-2021200773 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Ex vivo study Peer reviewed |
|---|---|
| Population | Honey bee midgut |
| Intervention | Ibogaine |
| Topics | Ibogaine |
| Keywords | Ex vivo Midgut Antioxidant In vivo Gene Honey bee Pharmacology Botany Biochemistry Biotechnology |
| Citations | 2 |
| Key points | Ibogaine treatment induced up-regulation of the Sod1 gene in honey bee midgut, suggesting a pro-antioxidant action. |
Abstract
HIGHLIGHTS The ibogain action has not been completely clarified. Honey bee midgut is suitable model system for testing the antioxidative mechanisms. The ex vivo ibogaine treatment induced an up-regulation of Sod1 gene. Ibogaine shows pro-antioxidant action.