Long-QT Syndrome Induced by the Antiaddiction Drug Ibogaine
Dianne W. M. Hoelen, Wilko Spiering, Gerlof D. Valk
New England Journal of Medicine January 14, 2009 DOI: 10.1056/nejmc0804248 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 31-year-old woman |
| Intervention | Ibogaine |
| Dose | 3.5 g |
| Topics | Ibogaine |
| Citations | 48 |
| Key findings | A single 3.5-g dose of ibogaine was associated with a seizure-like attack and severe QT prolongation (548 msec) with ventricular arrhythmias, indicating significant cardiac risk. |
Abstract
A 31-year-old woman was admitted to the emergency department because of a seizure-like attack after a single 3.5-g dose of ibogaine. ECG showed a severe prolonged-QT interval of 548 msec and ventri...
Comparable studies
Other case reports and case series on ibogaine for addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder. 31-year-old male military veteran with moderate alcohol use disorder | 2018 | Case study | n = 1 |
| Remission of Severe Opioid Use Disorder with Ibogaine: A Case Report. 37-year-old female with severe opioid use disorder | 2016 | Case study | n = 1 |
| Ibogaine Consumption With Seizure-Like Episodes, QTc-Prolongation, and Captured Cardiac Dysrhythmias. 34-year-old white woman with heroin and cocaine use disorder | 2019 | Case study | n = 1 |
| Novel treatment of opioid use disorder using ibogaine and iboga in two adults Individuals with opioid use disorder accessing ibogaine through private unregulated... | 2020 | Case series | n = 2 |
| Risk management in a global market of alternative addiction care: a case study of the ibogaine medical subculture | 2025 | Case study |
Citations in the library
Cited by 28
- Clinical applications of hallucinogens: A review. Experimental and Clinical Psychopharmacology August 1, 2016
- The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation Molecules January 29, 2015
- Treating drug dependence with the aid of ibogaine: a retrospective study. Journal of Psychopharmacology November 1, 2014
- Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes. Frontiers in Pharmacology 2018
- Fatalities temporally associated with the ingestion of ibogaine. Journal of Forensic Sciences March 1, 2012
and 23 more in the library
Cites 3
- Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Journal of Neuroscience January 19, 2005
- Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction. Medical Hypotheses 2006
- Ibogaine Therapy: A 'Vast, Uncontrolled Experiment' Science April 14, 2005