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Psychedelics, Harm Reduction, and Life's Big Questions: Making Sense of Spirituality and Religion After the Journey

Lisa L. Gezon, Kenton Bartlett

Anthropology of Consciousness August 27, 2025 DOI: 10.1111/anoc.70010 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Ethnographic study Peer reviewed
Population Members of a psychedelic integration group in the Southeastern U.S.
Topics Mysticism
Keywords Spirituality Religious experience Harm Thematic analysis Mental health Ethnography Mental illness Psychotherapist Qualitative research Religious studies Theology Social science Alternative medicine Anthropology
Citations 1
Key findings Psychedelic encounters helped some to resolve religious conflicts and nearly all reported a greater sense of spiritual connection, while challenges included religious condemnation, absent experiences, and difficulties interpreting ineffable occurrences.

Abstract

ABSTRACT The interplay between psychedelic use, mental health, and spiritual, religious, or ‘mystical’ experiences continues to be investigated through clinical research. While many studies focus on general mechanisms underlying these compounds, analysis of real‐life accounts from individuals is underrepresented. To fill that gap, this ethnographic study explores the question of how members of a psychedelic integration group in the Southeastern U.S. perceive the impact of psychedelics on their spiritual and religious outlook. Thematic analysis revealed that psychedelic encounters helped some to resolve religious conflicts, such as estrangement from religion or adverse religious associations, while nearly all reported a greater sense of spiritual connection. Noted challenges included perceived or actual religious condemnation of psychedelics, the absence of sought‐after experiences, and difficulties interpreting ineffable occurrences. Findings reinforce the need for attention to spirituality when addressing psychedelic use and mental health, arguing that doing so reduces harm and optimizes benefits.

Comparable studies

Other qualitative studies on mysticism, most cited first.

Study Year Design Participants
Qualitative and Quantitative Features of Music Reported to Support Peak Mystical Experiences during Psychedelic Therapy Sessions Individuals with extensive experience administering psilocybin or psilocybin-containing... 2017 Survey and qualitative/quantitative analysis n = 10
Common Core Thesis and Qualitative and Quantitative Analysis of Mysticism in Chinese Buddhist Monks and Nuns Chinese Pure Land and Chan Buddhist monks and nuns 2011 Mixed-methods study n = 139
Do Drugs Have Religious Import? A 40-Year Retrospective 2004 Interview
Narratives of the mystical among users of psychedelics Psychedelic drug users 2021 Qualitative study n = 50
Auras in mysticism and synaesthesia: a comparison. Synaesthetes who experience colors in response to human faces and figures 2012 Qualitative study n = 4

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