Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly
Biological Psychiatry October 15, 2009 Yvette I. Sheline, Marcus E. Raichle, Abraham Z. Snyder et al. 608 citations
BackgroundImportant functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta (Abeta) plaque-associated neuronal toxicity. Here, we sought to determine if pathological effects of Abeta amyloid plaques could be seen, even in the absence of a task, by examining functional connectivity in cognitively normal participants with...