Mescaline action on “memory decay” and “problem solving” behavior in the rat
L Molinengo, M.c. Cassone, Alessandra Baroli, Marco Orsetti
Progress in Neuro-Psychopharmacology and Biological Psychiatry 1986 DOI: 10.1016/0278-5846(86)90055-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Mescaline |
| Dose | 30 mg/kg/day |
| Topics | Mescaline |
| Keywords | Doors Conditioned reflex Action physics Anesthesia Pharmacology Hallucinogen |
| Citations | 2 |
| Key findings | Mescaline at 30 mg/kg/day accelerated conditioned reflex decay and increased door-opening time and food consumption in rats. |
Abstract
The modifications of behavior caused in the rat by a chronic oral administration of mescaline have been studied in three experimental situations. In the staircase maze mescaline accelerated the spontaneous decay on the conditioned reflex (memory decay) during the period without daily training. Only the results observed at 30 mg/kg/day of mescaline were statistically significant. In a T maze two lateral alleys closed by two swinging doors, 30 mg/kg/day of mescaline increased the time spent in opening the first door. When the two doors of the lateral alleys were closed with a latch, mescaline 30 mg/kg/day, caused an increase in the time spent by the rat in opening the doors. Mescaline caused an increase in food consumption. The increase at 30 mg/kg/day is statistically significant.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
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| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |