Action of a chronic administration of mescaline in dynamic behavioural situations
A Fundarò, L Molinengo, M.c. Cassone, Marco Orsetti
Progress in Neuro-Psychopharmacology and Biological Psychiatry 1986 DOI: 10.1016/0278-5846(86)90042-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | mescaline |
| Dose | 4 mg/kg/day, 10 mg/kg/day, 9 mg/kg/day |
| Topics | Mescaline |
| Keywords | Lever Reinforcement Conditioning Schedule Pharmacology Anesthesia Developmental psychology Plant-based medicinal research |
| Citations | 4 |
| Key findings | Chronic mescaline at 4 mg/kg/day blocked rats' ability to switch to a newly reinforced lever in a reversal test, while 9 mg/kg/day had an excitatory effect that increased reinforced responses beyond controls. |
Abstract
The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning. In the "periodic conditioning" test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg/day and 10 mg/kg/day) caused no modification of the ability of the rat to adapt its behaviour to the new experimental situation. In the "reversal test" the contingency for food delivery was switched from one lever, where responses were previously reinforced to the other lever where responses had no programmed consequences. A chronic administration of mescaline (4 mg/kg/day) caused a total incapacity of the rat to switch to the lever which became reinforced in the reversal trial. A chronic administration of 9 mg/kg/day of mescaline had an excitatory effect and the number of reinforced responses in the II and III reversals exceeded the unreinforced responses in a measure greater than in the controls.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 2
Cites 4
- Chronic Users of LSD: The "Acidheads" American Journal of Psychiatry September 1, 1968
- Behavioral effects of intracerebroventricular administration of LSD, DOM, mescaline or lisuride Pharmacology, Biochemistry, and Behavior August 1, 1984
- Central 5-hydroxytryptamine and the effects of hallucinogens and phenobarbital on operant responding in rats. Pharmacology, Biochemistry, and Behavior May 1981
- Behavioral effects of LSD in the cat: proposal of an animal behavior model for studying the actions of hallucinogenic drugs. Brain Research August 1, 1977