Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice
María Pilar García-pardo, Marta Rodrı́guez-arias, Concepción Maldonado, Carmen Manzanedo, José Miñarro, María A. Aguilar
Behavioural Pharmacology September 1, 2014 DOI: 10.1097/fbp.0000000000000065 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Adolescent (postnatal day 29-40) and adult (postnatal day 50-61) male mice |
| Interventions | social defeat stress MDMA |
| Dose | 1.25 or 10 mg/kg |
| Topics | Anxiety MDMA |
| Keywords | Social defeat Anxiogenic Conditioned place preference Agonistic behaviour Social stress Corticosterone Conditioning Developmental psychology Affect linguistics Endocrinology Dopamine Aggression Anxiolytic Hormone Communication |
| Citations | 29 |
| Key findings | Social defeat stress decreases the sensitivity of adult mice to the rewarding effects of MDMA, as measured by conditioned place preference. |
Abstract
Exposure to social defeat stress increases the rewarding effects of psychostimulants in animal models, but its effect on 3,4-methylenedioxymethylamphetamine (MDMA) reward has received little attention. In the present study, we evaluated the influence of social defeat on the rewarding effects of MDMA in adolescent [postnatal day (PND) 29-40] and adult (PND 50-61) male mice using the conditioned place preference paradigm. Experimental mice were exposed to social defeat in an agonistic encounter before each session of conditioning with 1.25 or 10 mg/kg of MDMA. The effects of social defeat on corticosterone levels and the motor or the anxiogenic effects of MDMA were also evaluated. Mice exposed to social defeat during adulthood did not show conditioned place preference after conditioning with either dose of MDMA. Conversely, social defeat did not affect the anxiogenic and motor effects of MDMA. Adult mice exposed to social defeat showed higher levels of corticosterone than their controls and adolescent mice. Social stress did not induce behavioural effects in adolescent mice. Our results show that stress induced by social defeat decreases the sensitivity of adult mice to the rewarding effects of MDMA.
Comparable studies
Other preclinical and animal studies on MDMA for anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning Mice | 2015 | Preclinical experimental study | |
| MDMA in Adolescent Male Rats Adolescent male rats (postnatal day 45) | 2006 | Controlled experiment | n = 12 |
| Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents Rodents | 2024 | Review | |
| Differential behavioral outcomes of 3,4-methylenedioxymethamphetamine (MDMA-ecstasy) in anxiety-like responses in mice 2-month-old Balb/c male mice (25-35 g) | 2013 | Observational study | n = 70 |
| Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA Rats | 2024 | Preclinical study |
Citations in the library
Cited by 6
- Involvement of NMDA glutamate receptors in the acquisition and reinstatement of the conditioned place preference induced by MDMA Behavioural Pharmacology May 14, 2015
- The effects of acute and repeated adolescent MDMA exposure on behavior, cognition, and the monoamine neurotransmitter systems: A review of human and pre-clinical research Behavioural Brain Research February 10, 2026
- Of mice and men on MDMA: a translational comparison of the neuropsychobiological effects of 3,4-methylenedioxymethamphetamine ('Ecstasy'). Brain Research November 14, 2019
- Cognitive and behavioural effects induced by social stress plus MDMA administration in mice. Behavioural Brain Research February 15, 2017
- Neurochemical substrates of the rewarding effects of MDMA: implications for the development of pharmacotherapies to MDMA dependence. Behavioural Pharmacology April 2016
and 1 more in the library
Cites 19
- Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens Journal of Psychoactive Drugs October 1, 1986
- MDMA Self-Administration in Laboratory Animals: A Summary of the Literature and Proposal for Future Research Neuropsychobiology 2009
- Dopaminergic mechanisms of reinstatement of MDMA‐seeking behaviour in rats British Journal of Pharmacology December 30, 2010
- Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour The International Journal of Neuropsychopharmacology October 14, 2010
- PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence Addiction Biology September 8, 2009
and 14 more in the library