Long-term effects of repeated social stress on the conditioned place preference induced by MDMA in mice.
María P García-Pardo, M C Blanco-Gandía, M Valiente-Lluch, Marta Rodríguez‐arias, José Miñarro, María A. Aguilar
Progress in Neuro-Psychopharmacology and Biological Psychiatry December 3, 2015 DOI: 10.1016/j.pnpbp.2015.06.006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Adolescent and young adult mice |
| Dose | 1.25 or 10 mg/kg i.p. |
| Duration | Conditioned three weeks after social defeat; long-term effects evaluated in adult mice |
| Measures | conditioned place preference (CPP), priming-induced reinstatement, anxiety-like behavior, social interaction, maze learning |
| Topics | MDMA |
| Keywords | Adolescence Conditioned place preference Mice Repeated social defeat |
| Key findings | Repeated social defeat stress increased the rewarding effects of MDMA in mice, shown by enhanced priming-induced reinstatement at 1.25 mg/kg and longer-lasting conditioned place preference at 10 mg/kg. Stressed mice also showed increased anxiety-like behavior, altered social interaction, and impaired maze learning. The authors argue these findings suggest stress may increase vulnerability to MDMA dependence. |
Abstract
Previous studies have demonstrated that social defeat stress increases the rewarding effects of psychostimulant drugs such as cocaine and amphetamine. In the present study we evaluated the long-term effects of repeated social defeat (RSD) on the rewarding effects of ±3,4-methylenedioxymethamphetamine (MDMA) hydrochloride in the conditioned place preference (CPP) paradigm. Adolescent and young adult mice were exposed to four episodes of social defeat (on PND 29-40 and PND 47-56, respectively) and were conditioned three weeks later with 1.25 or 10mg/kg i.p. of MDMA (experiment 1). The long-term effects of RSD on anxiety, social behavior and cognitive processes were also evaluated in adult mice (experiment 2). RSD during adolescence enhanced vulnerability to priming-induced reinstatement in animals conditioned with 1.25mg/kg of MDMA and increased the duration of the CPP induced by the 10mg/kg of MDMA. The latter effect was also observed after RSD in young adult mice, as well as an increase in anxiety-like behavior, an alteration in social interaction (reduction in attack and increase in avoidance/flee and defensive/submissive behaviors) and an impairment of maze learning. These results support the idea that RSD stress increases the rewarding effects of MDMA and induces long-term alterations in anxiety, learning and social behavior in adult mice. Thus, exposure to stress may increase the vulnerability of individuals to developing MDMA dependence, which is a factor to be taken into account in relation to the prevention and treatment of this disorder.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
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- A Systematic Review of the MDMA Model to Address Social Impairment in Autism. Current Neuropharmacology 2021
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- Cognitive and behavioural effects induced by social stress plus MDMA administration in mice. Behavioural Brain Research February 15, 2017
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Cites 7
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- PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence Addiction Biology September 8, 2009
- Involvement of NMDA glutamate receptors in the acquisition and reinstatement of the conditioned place preference induced by MDMA Behavioural Pharmacology May 14, 2015
- Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice Behavioural Pharmacology September 1, 2014
- Adolescent pre‐exposure to ethanol and 3,4‐methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding effects of MDMA and drug‐induced reinstatement Addiction Biology October 13, 2011
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