Behavioural Pharmacology
May 14, 2015
María Pilar García-pardo, Carla Escobar-Valero, Marta Rodrı́guez-arias et al.
29 citations
Some 3,4-methylenedioxymethamphetamine (MDMA) users become dependent as a result of chronic consumption. A greater understanding of the neurobiological basis of the rewarding effects of MDMA could contribute to developing effective pharmacotherapies for MDMA-related problems. The present study evaluated the role of N-methyl-D-aspartate (NMDA) glutamate receptors (NMDARs) in the acquisition and...
Behavioural Pharmacology
September 1, 2014
María Pilar García-pardo, Marta Rodrı́guez-arias, Concepción Maldonado et al.
29 citations
Exposure to social defeat stress increases the rewarding effects of psychostimulants in animal models, but its effect on 3,4-methylenedioxymethylamphetamine (MDMA) reward has received little attention. In the present study, we evaluated the influence of social defeat on the rewarding effects of MDMA in adolescent [postnatal day (PND) 29-40] and adult (PND 50-61) male mice using the conditioned...
Psychopharmacology
November 2011
Marta Rodríguez-Arias, Concepción Maldonado, Antonio Vidal-Infer et al.
Heavy binge drinking is increasingly frequent among adolescents, while ethanol (EtOH) is often used in combination with 3,4-methylenedioxymethamphetamine (MDMA). The long-lasting effects of intermittent exposure to EtOH and MDMA during adolescence on motor activity, anxiety, and social behavior were evaluated in adult mice. The concentration of brain monoamines in the striatum, cortex, and...
Pharmacology, biochemistry, and behavior
November 2011
M Daza-Losada, J Miñarro, M A Aguilar et al.
Cannabis is one of the drugs most commonly consumed in combination with ecstasy (3,4-methylenedioxymethamphetamine, MDMA). Although numerous studies have attempted to further our understanding of the role of the cannabinoid system in drug abuse, few have focused on how it influences the rewarding effects of MDMA. The aim of the present study was to evaluate the role of the CB1 cannabinoid...
Addiction Biology
October 13, 2011
Bruno Ribeiro Do Couto, Manuel Daza‐losada, Marta Rodrı́guez-arias et al.
26 citations
ABSTRACT Many adolescents often take ethanol (EtOH) in combination with 3,4‐methylenedioxymethylamphetamine (MDMA). In the present work, we used a mouse model to study the effect of repeated pre‐exposure during adolescence to EtOH (2 g/kg), MDMA (10 or 20 mg/kg) or EtOH + MDMA on the rewarding and reinstating effects of MDMA in the conditioned place preference (CPP) paradigm. Pre‐exposure to...
Behavioral and Brain Functions
March 22, 2010
Carmen Manzanedo, Marta Rodríguez‐arias, Manuel Daza‐losada et al.
36 citations
Abstract Background Numerous reports indicate that MDMA users consume other psychoactive drugs, among which cannabis is one of the most common. The aim of the present study was to evaluate, using the conditioned place preference, the effect of the cannabinoid agonist WIN 55,212-2 on the rewarding effects of MDMA in mice. Methods In the first experiment adolescent mice were initially conditioned...
Addiction Biology
September 8, 2009
Manuel Daza‐losada, Marta Rodríguez‐arias, María A. Aguilar et al.
37 citations
ABSTRACT Those who take ecstasy are more likely to consume other drugs than non‐users with cocaine abuse being reported by 75.5% of high school student MDMA (± 3,4‐methylenedioxymetamphetamine hydrochloride) users. The aim of this work was to evaluate the effects of exposure during adolescence to MDMA, cocaine or to both drugs on the MDMA‐induced conditioned place preference (CPP) in adult...