Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA)
Matthew B Young, Seth D. Norrholm, Lara M. Khoury, Tanja Jovanović, Sheila A. M. Rauch, Collin Reiff, Boadie W Dunlop, Barbara O Rothbaum, Leonard L. Howell
Psychopharmacology July 24, 2017 DOI: 10.1007/s00213-017-4684-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Translational behavioral model Peer reviewed |
|---|---|
| Intervention | MDMA |
| Topics | MDMA Serotonin |
| Keywords | Serotonin transporter Extinction optical mineralogy Pharmacology Biochemistry Receptor |
| Citations | 103 |
| Key points | MDMA enhances fear memory extinction, and this effect requires the serotonin transporter and 5-HT2A receptors. |
Abstract
We validate enhancement of fear memory extinction by MDMA in a translational behavioral model, and reveal the importance of 5-HTT and 5-HT2A receptors to this effect. These observations support future clinical research of MDMA as an adjunct to exposure therapy, and provide important pharmacological considerations for clinical use in a population frequently treated with 5-HTT inhibitors.
Citations in the library
Cited by 76
- Global Street Food: la cocina de la calle Diseño interior 2009
- Oxytocin-dependent reopening of a social reward learning critical period with MDMA Nature April 3, 2019
- Psychedelics reopen the social reward learning critical period Nature June 14, 2023
- Reviewing the Potential of Psychedelics for the Treatment of PTSD The International Journal of Neuropsychopharmacology March 12, 2020
- Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine Journal of Neuroscience November 30, 2020
and 71 more in the library
Cites 19
- The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. Journal of Psychopharmacology July 19, 2010
- Subjective Reports of the Effects of MDMA in a Clinical Setting Journal of Psychoactive Drugs October 1, 1986
- Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. Journal of Psychopharmacology 2013
- Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Experimental Brain Research June 1, 2013
- Carrier‐Mediated Release of Serotonin by 3,4‐Methylenedioxymethamphetamine: Implications for Serotonin‐Dopamine Interactions Journal of Neurochemistry 1996
and 14 more in the library