Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats
James K. Walters, Michael H. Sheard, Michael T. Davis
Pharmacology, Biochemistry, and Behavior July 1, 1978 DOI: 10.1016/0091-3057(78)90016-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | N N-dimethyltryptamine 5-methoxy-N |
| Dose | DMT: 0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg; 5-MeO-DMT: 0.06, 0.12, 0.5, 2.0 mg/kg |
| Topics | LSD Serotonin 5-MeO-DMT DMT |
| Keywords | Hallucinogen Pharmacology Tryptamine |
| Citations | 18 |
| Key findings | Both N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine inhibited shock-elicited fighting in rats at higher doses, with no significant effects at lower doses. |
Abstract
Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses. The effects of these drugs on shock elicited fighting, as well as on other behaviors, thus differ from those of another indole hallucinogen, d-lysergic acid diethylamide, and are discussed in relation to their effects on single unit activity of the raphe-serotonin system and their interaction with other neurotransmitter systems.
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |
Citations in the library
Cited by 13
- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Chronic, Intermittent Microdoses of the Psychedelic N , N -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents ACS Chemical Neuroscience March 4, 2019
- Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT) ACS Chemical Neuroscience July 23, 2018
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
and 8 more in the library