Influence of LSD-25 on optically evoked potentials in the nonanesthetized rabbit
American Journal of Physiology-Legacy Content June 1, 1959 DOI: 10.1152/ajplegacy.1959.196.6.1181 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Chronically prepared unanesthetized and noncurarized rabbits |
| Intervention | LSD-25 (i.v.) |
| Dose | 35 µg/animal |
| Duration | 23-hour period |
| Topics | LSD |
| Keywords | Latency audio Rabbit cipher Anesthesia Pharmacology |
| Citations | 12 |
| Key findings | LSD-25 enhanced optically evoked cortical potentials for over six hours, reduced latency by about 10%, and greatly reduced variability of amplitude and latency for 1–3 hours after injection. |
Abstract
The influence of LSD-25 (i.v.) upon the optically evoked cortical potentials was studied in chronically prepared unanesthetized and noncurarized rabbits over a 23-hour period. With moderate doses of the drug (35 µg/animal) the potentials were enhanced for a period of over 6 hours. The time course of the amplitudes indicates a triphasic pattern. LSD-25 reduced the latency of the potentials by about 10%. LSD-25 was found to have a marked effect upon variability of both the amplitude and the latency. Both these variabilities were greatly reduced for 1–3 hours after injection.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |