Effects of LSD-25 on Food Intake in the Rat.
Charles Hamilton, Chester R. Wilpizeski
Experimental Biology and Medicine November 1, 1961 DOI: 10.3181/00379727-108-26925 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Duration | 10 daily injections |
| Topics | LSD |
| Keywords | Food intake Reinforcement Physiology Food science Endocrinology Toxicology |
| Citations | 13 |
| Key findings | LSD-25 suppresses food intake in rats in a dose-dependent manner, and repeated daily injections do not lead to complete tolerance. |
Abstract
Suppression of food intake in the rat was shown to follow injection of LSD-25 and this effect was determined to be dose dependent. When the effects of 10 daily injections of the drug were investigated, a suppression of food intake on each day indicated a lack of development of complete tolerance. These data show that caution is needed in interpretation of the behavioral effects of LSD-25 where such behavior is dependent upon food reinforcement.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 3
- Pharmacological and behavioral components of tolerance to LSD and mescaline in rats Pharmacology, Biochemistry, and Behavior September 1, 1977
- A pharmacological comparison of 3-methoxy-4,5-methylenedioxyamphetamine and LSD in the dog. Drug and Alcohol Dependence May 1, 1978
- Effects of acute lysergic acid diethylamide on intermittent ethanol and sucrose drinking and intracranial self-stimulation in C57BL/6 mice. Journal of Psychopharmacology July 2022