Behavioral sensitivity to LSD: Dependency upon the pattern of central 5HT depletion
James A. Joseph, James B. Appel
Pharmacology, Biochemistry, and Behavior May 1, 1977 DOI: 10.1016/0091-3057(77)90108-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | p-chloroamphetamine 5 7-dihydroxytryptamine p-chlorophenylalanine LSD |
| Dose | 0.02 mg/kg |
| Duration | 12 days after 5,7-DHT administration |
| Topics | Serotonin LSD |
| Keywords | 5,7-dihydroxytryptamine 5-HT Receptor P-chloroamphetamine Sensitivity control systems Endocrinology Pharmacology |
| Citations | 18 |
| Key findings | Only 5,7-dihydroxytryptamine, not p-chloroamphetamine, increased sensitivity to a low dose of LSD, disrupting bar-press behavior, suggesting a specific pattern of serotonin depletion is required. |
Abstract
Two experiments were carried out using a fixed ratio (FR) schedule of water reinforcement to determine the efficacy of two serotonin (5HT) depleting agents (p-chloroamphetamine, 5, 7-dihydroxytryptamine) in altering sensitivity to a low dose of LSD (0.02 MG/KG). The results showed that while both p-chloroamphetamine (PCA) and 5, 7 dihydroxytryptamine (5, 7 DHT) were efficacious in reducing whole brain 5HT, only 5, 7 DHT altered LSD sensitivity such that a 0.02 mg/kg dose of LSD given 12 days after 5, 7 DHT administration disrupted bar press behavior. This was not observed in animals given PCA within similar parameters. Moreover, 4 animals given PCA that did not show increased sensitivity to LSD, did show behavioral disruption to LSD (0.02 mg/kg when they were pretreated with p-chlorophenylalanine, Results are discussed on terms of a possible particular pattern of 5HT depletion that must be achieved before sensitivity to LSD is observed.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 11
- Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline European Journal of Pharmacology 1989
- Naloxone potentiates the disruptive effects of mescaline on operant responding in the rat Pharmacology, Biochemistry, and Behavior October 1, 1980
- Early preclinical studies of discriminable sedative and hallucinogenic drug effects. Psychopharmacology April 2009
- The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion. Psychopharmacology October 1995
- The effects of intracranial administration of hallucinogens on operant behavior in the rat. II. 2,5-Dimethoxy-4-methylamphetamine (DOM). Pharmacology, Biochemistry, and Behavior November 1987
and 6 more in the library