Comparative subjective effects of seven drugs including lysergic acid diethylamide (LSD-25).
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch
Journal of Abnormal & Social Psychology November 1, 1955 DOI: 10.1037/h0041073 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Within-subjects experimental Peer reviewed |
|---|---|
| Sample size | 5 |
| Population | Human participants |
| Interventions | ethyl alcohol scopolamine BOL-148 methamphetamine LAE-32 LSD-25 |
| Dose | average effective dose |
| Duration | 4.5 hours after administration |
| Topics | LSD |
| Keywords | Hallucinogen Clinical psychology |
| Citations | 32 |
| Key findings | LSD-25 produced the most frequent and largest positive responses among the seven drugs tested. |
Abstract
Five Ss were tested on nine occasions under two placebos of tap water and under an average effective dose of 7 drugs--ergometerine (Ergonovine), ethyl alcohol, scopolamine (hyroscine), d-1-brom lysergic acid diethylamide (BOL-148), methamphetamine hydrochloride (Methedrine or Pervitin), lysergic acid monoethylamide (LAE-32), and lysergic acid diethylamide (LSD-25) during 9 different experimental sessions . . ... The Ss completed a questionnaire inquiring about their perceptual, physiological and cognitive state before they received the drug or placebo and .5, 2.5 and 4.5 hours after receiving it . . ... Although differentiation between 3 lysergic acid derivatives, Ergonovine, LAE-32, and BOL-148, and between alcohol, methamphetamine, and scopolamine was not clear cut, the number of responses to the questionnaire under these drugs was clearly greater than those given under water . . ... LSD-25 clearly produced the most frequent and the largest positive responses. (PsycINFO Database Record (c) 2006 APA, all rights reserved)
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 5
- Psychopharmacological Studies of Lysergic Acid Diethylamide (LSD-25) Intoxication A M A Archives of Neurology & Psychiatry December 1, 1957
- Effects of LSD-25 on Tests of Personality Journal of Mental Science October 1, 1958
- Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation? British Journal of Pharmacology July 28, 2025
- Mistyczna transformacja. Substancje psychedeliczne w leczeniu zaburzeń psychicznych Studia Krytyczne/Critical Studies January 9, 2019
- Theories of Depersonalization: A Re-appraisal The British Journal of Psychiatry July 1, 1970