Effects of LSD-25 on the EEG and Photic Evoked Responses
Archives of General Psychiatry April 1, 1966 DOI: 10.1001/archpsyc.1966.01730100099013 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Population | Humans |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Electroencephalography Photic stimulation Alpha rhythm Audiology |
| Citations | 30 |
| Key findings | LSD-25 decreases EEG amplitude, suppresses alpha rhythms, and increases alpha frequencies by 0.5 to 4 cycles per second. |
Abstract
SINCE the accidental discovery of the Psychosomimetic properties of Lysergic acid diethylamide (LSD-25) by Stoll,1in 1947, a great amount of work has been carried out to elucidate the behavioral effects and pathophysiological mechanisms of action of this substance. The literature on this topic is steadily growing and contains now more than 1,000 publications.2 There are several studies available that report on the electroencephalographic changes resulting from LSD administration to humans as seen by surface recordings3-9and there are also some observations on changes in the human depth electrogram.10-13It is generally agreed that the amplitude of the EEG decreases, α-rhythms tend to disappear and the tracings become of the lowvoltage fast or desynchronized type. Gastaut4reported that the average α-frequencies are increased by 0.5 to 4 cycles per second (cps) and Grey Walter7noted an increase from 11.6 to
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 10
- The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas Brain February 28, 2010
- Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults Psychopharmacology October 6, 2021
- LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion. Human Brain Mapping April 29, 2016
- A Paradigm for the Study of Altered States of Consciousness The British Journal of Psychiatry October 1, 1968
- An Untoward Reaction to Accidental Ingestion of LSD in a 5-Year-Old Girl JAMA September 11, 1967
and 5 more in the library