Model Psychoses Induced by LSD-25 in Normals
A M A Archives of Neurology & Psychiatry June 1, 1956 DOI: 10.1001/archneurpsyc.1956.02330240026003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Historical analysis Peer reviewed |
|---|---|
| Topics | Cannabis Mescaline LSD |
| Keywords | Methaqualone Schizophrenia object-oriented programming Battle Psychosis Milestone Hallucinogen Psychoanalysis Ancient history |
| Citations | 35 |
| Key points | Argues that experimental psychosis research, from ancient Cannabis indica use to Beringer's mescaline experiments and Stoll and Hoffmann's discovery of LSD-25, has produced model psychoses resembling schizophrenia, with Stoll classifying LSD-25-induced psychosis as acute. |
Abstract
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the ancient Hun warriors, resulting in mental obfuscation, as they were prepared for surgery because of wounds sustained in battle. Scientific experimental psychiatry began toward the end of the last century, in the Kraepelinian era—when the organic theory of psychoses was in its fullest vogue. Beringer's experiments with mescaline1marked a milestone in research in that many of the symptoms induced were highly similar to those encountered in schizophrenia and the drug seemed to have had a selective affinity for the brain. The discovery of LSD-25* by Stoll and Hoffmann2was an even more exciting event, because the drug worked similarly in infinitesimal-trace amounts. Stoll3(1947) suggested the pharmacological designationPhantastiumfor this substance, and he classified the resultant model psychosis as that of the acute
Comparable studies
Other theoretical and historical papers on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The Experimental Use of Psychedelic (LSD) Psychotherapy | 1970 | Historical analysis | |
| LSD: My Problem Child | 1981 | Historical analysis | |
| On the Use and Abuse of LSD | 1968 | Theoretical or philosophical paper | |
| The Use of Music in Psychedelic (LSD) Psychotherapy | 1972 | Theoretical or philosophical paper | |
| Flashbacks: Recurrent Intrusive Images After the Use of LSD | 1969 | Theoretical or philosophical paper |
Citations in the library
Cited by 20
- The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas Brain February 28, 2010
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Biological Psychiatry November 29, 2014
- Psychedelics, Meditation, and Self-Consciousness Frontiers in Psychology September 4, 2018
- Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution Frontiers in Human Neuroscience May 23, 2017
- Waves of the Unconscious: The Neurophysiology ofDreamlikePhenomena and Its Implications for the Psychodynamic Model of the Mind Neuropsychoanalysis 2007
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Cites 6
- The Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1954
- LYSERGIC ACID DIETHYLAMIDE (LSD-25) American Journal of Psychiatry June 1, 1952
- EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25) American Journal of Psychiatry February 1, 1952
- Psychological Aspects of the Lsd Treatment of the Neuroses Journal of Mental Science April 1, 1954
- EXPERIMENTAL PHYSIOLOGICAL STUDIES WITH LYSERGIC ACID DIETHYLAMIDE (LSD-25) Archives of Neurology And Psychiatry May 1, 1951
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