REVERSAL LEARNING ENHANCED BY LYSERGIC ACID DIETHYLAMIDE (LSD): CONCOMITANT RISE IN BRAIN 5‐HYDROXYTRYPTAMINE LEVELS
Alan R. King, Ian L. Martin, Kathleen Melville
British Journal of Pharmacology November 1, 1974 DOI: 10.1111/j.1476-5381.1974.tb08611.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | LSD |
| Dose | 12.5–50 μg/kg (LSD), 25 μg/kg (BOL-148) |
| Topics | LSD Serotonin |
| Keywords | Concomitant Pharmacology Hallucinogen |
| Citations | 38 |
| Key findings | LSD, but not its non-hallucinogenic analogue BOL-148, facilitated learning of a brightness discrimination reversal and slightly increased brain serotonin levels in rats. |
Abstract
Small doses of lysergic acid diethylamide (LSD) (12.5–50 μg/kg) consistently facilitated learning of a brightness discrimination reversal. 2‐Bromo‐lysergic acid diethylamide (BOL‐148), a structural analogue of LSD, with similar peripheral anti‐5‐hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg). LSD, but not BOL‐148, caused a small but significant increase in brain 5‐hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 μg/kg.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 23
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- Pivotal mental states Journal of Psychopharmacology April 1, 2021
- Psilocybin for treating substance use disorders? Expert Review of Neurotherapeutics August 10, 2016
and 18 more in the library
Cites 4
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25 British Journal of Pharmacology October 1, 1970
- Lysergic Acid Diethylamide New England Journal of Medicine February 22, 1968
- Effects of LSD-25 on brain serotonin. Journal of Pharmacology and Experimental Therapeutics November 1, 1961