The Use of LSD-25 as a Diagnostic Aid in Doubtful Cases of Schizophrenia
The British Journal of Psychiatry 1965 DOI: 10.1192/bjp.111.470.96 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | LSD-25 |
| Topics | LSD |
| Keywords | Schizophrenia object-oriented programming Exacerbation Childhood schizophrenia Personality Value mathematics Clinical psychology Psychoanalysis |
| Citations | 14 |
| Key findings | LSD-25 exacerbates existing psychiatric symptoms by weakening central functions and defense systems, and tends to exaggerate catatonic and hebephrenic features in schizophrenics while producing a caricature of personality in normal subjects. |
Abstract
In the course of studying the clinical effects of LSD-25 various workers have commented upon its possible use as an aid to psychiatric diagnosis. Stoll (1947) and Becker (1949) considered it to be of limited value in this respect. Condrau (1949) pointed out that it tended to exaggerate catatonic and hebephrenic features in schizophrenics and to produce a caricature of the personality in normal subjects; the latter point also being made by Anderson and Rawnsley (1954). Von Felsinger et al . (1956) considered the primary psychological effect of the drug to be an exacerbation of existing symptomatology, through a weakening of central functions and defence systems.
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 4
- Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia? Cambridge University Press eBooks February 4, 2010
- Beyond Psilocybin: Reviewing the Therapeutic Potential of Other Serotonergic Psychedelics in Mental and Substance Use Disorders Journal of Psychoactive Drugs August 24, 2023
- The intersection between psychedelics and schizophrenia spectrum disorders: Reevaluating risk and therapeutic potential. Journal of Psychopharmacology June 25, 2026
- Depersonalization in a Group of Normal Subjects The British Journal of Psychiatry September 1, 1966