Immunological Consequences of In Vitro Exposure to Lysergic Acid Diethylamide (LSD)
Robert V. House, Peter J. Thomas, Hemendra N. Bhargava
Immunopharmacology and Immunotoxicology 1994 DOI: 10.3109/08923979409029898 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro experimental study Peer reviewed |
|---|---|
| Population | Human immune cells in culture |
| Intervention | LSD |
| Dose | 100 microM, 0.0001 to 0.1 microM |
| Topics | LSD |
| Keywords | In vitro Immune system Cytotoxicity Immunology Pharmacology Natural killer cell Cytotoxic t cell |
| Citations | 45 |
| Key findings | LSD suppresses B-lymphocyte proliferation, cytokine production, and cytotoxic T-lymphocyte induction at 100 microM, while enhancing natural killer cell activity at lower concentrations between 0.0001 and 0.1 microM. |
Abstract
The ability of lysergic acid diethylamide (LSD) to alter immune function after direct in vitro exposure was examined. It was demonstrated that LSD is able to suppress the proliferation of B-lymphocytes; the production of the cytokines IL-2, IL-4, and IL-6; and the induction of cytotoxic T-lymphocytes at a concentration of 100 microM. In vitro exposure to LSD had differential effects on natural killer (NK) cell activity, with significant enhancement of both basal and IL-2-augmented NK cell function at concentrations between 0.0001 and 0.1 microM, and suppression of NK response at 100 microM. These results demonstrate that LSD may have a direct effect on components of the immune system at concentrations that may be reached upon human exposure.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
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