Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
Patrick C. Dolder, Yasmin Schmid, Manuel Haschke, Katharina Rentsch, Matthias E. Liechti
The International Journal of Neuropsychopharmacology June 24, 2015 DOI: 10.1093/ijnp/pyv072 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pharmacokinetic study Peer reviewed |
|---|---|
| Population | Healthy adults |
| Intervention | Lysergic acid diethylamide |
| Topics | LSD |
| Keywords | Pharmacokinetics Urine Pharmacology Active metabolite Oral administration Pharmacodynamics |
| Citations | 110 |
| Key points | LSD exhibits dose-proportional pharmacokinetics with a terminal half-life of 3.6 hours and effects lasting up to 12 hours. |
Abstract
These first data on the pharmacokinetics and concentration-effect relationship of oral lysergic acid diethylamide are relevant for further clinical studies and serve as a reference for the assessment of intoxication with lysergic acid diethylamide.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 90
- Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences April 11, 2016
- Crystal structure of an LSD-bound human serotonin receptor Cell January 26, 2017
- Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European Neuropsychopharmacology May 20, 2016
- Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies Acta Psychiatrica Scandinavica October 30, 2020
- The paradoxical psychological effects of lysergic acid diethylamide (LSD) Psychological Medicine February 5, 2016
and 85 more in the library
Cites 11
- Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases The Journal of Nervous and Mental Disease March 4, 2014
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Biological Psychiatry November 29, 2014
- THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE Annals of the New York Academy of Sciences March 1, 1957
- The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (“Ecstasy”) in Humans Clinical Pharmacology & Therapeutics June 15, 2011
and 6 more in the library