LSD Psychosis or LSD-Induced Schizophrenia?
Archives of General Psychiatry August 1, 1983 DOI: 10.1001/archpsyc.1983.01790070067008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 81 |
| Population | Patients hospitalized for LSD psychosis and matched first-break schizophrenics |
| Duration | 3-5 year follow-up |
| Topics | LSD |
| Keywords | Psychosis Schizophrenia object-oriented programming Clinical psychology Population Hallucinogen |
| Citations | 145 |
| Key findings | LSD psychotics were fundamentally similar to schizophrenics in genealogy, phenomenology, and course of illness, supporting a model of drug-induced schizophreniform reaction. |
Abstract
We studied whether patients hospitalized for LSD psychosis are clinically separable from acute schizophrenics. The family histories, manifest symptoms, premorbid adjustment, and profiles on an extensive test battery were analyzed for 52 LSD psychotics and 29 matched first-break schizophrenics. The LSD patients did not differ from schizophrenics in incidence of psychosis or suicide among the parents. However, the rate of parental alcoholism for LSD psychotics far exceeded that for schizophrenics and the general population. The two groups were distinguished on some clinical features but were equivalent in premorbid adjustment, on most cognitive measures when initially hospitalized or reassessed three to five years later, and in number of subsequent rehospitalizations. Thus, in most respects the LSD psychotics were fundamentally similar to schizophrenics in geneaology, phenomenology, and course of illness. The findings supported a model of LSD psychosis as a drug-induced schizophreniform reaction in persons vulnerable to both substance abuse and psychosis.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 35
- Psychedelics and Mental Health: A Population Study PLoS One August 19, 2013
- Drug-Induced Psychosis: How to Avoid Star Gazing in Schizophrenia Research by Looking at More Obvious Sources of Light Frontiers in Behavioral Neuroscience 2011
- Altered network hub connectivity after acute LSD administration NeuroImage: Clinical March 7, 2018
- Diversity of Psychopathology Associated with use of 3,4-Methylenedioxymethamphetamine (‘Ecstasy’) The British Journal of Psychiatry September 1, 1994
- The psychopharmacology of hallucinogens. Neuropsychopharmacology April 1, 1996
and 30 more in the library
Cites 7
- The "Bad Trip"—The Etiology of the Adverse LSD Reaction American Journal of Psychiatry May 1, 1968
- Organicity Measures Following Repeated LSD Ingestion Archives of General Psychiatry December 1, 1969
- LSD: Personality and Experience British Journal of Addiction to Alcohol & Other Drugs December 1, 1973
- A Statistical Survey of Adverse Reactions to LSD in Los Angeles County American Journal of Psychiatry September 1, 1968
- Effects of LSD-25 on Relatives of Schizophrenic Patients Journal of Mental Science 1962
and 2 more in the library