Long-term Amelioration of OCD Symptoms in a Patient with Chronic Consumption of Psilocybin-containing Mushrooms
Agustín Lugo-Radillo, Jorge Luis Cortés-lópez
Journal of Psychoactive Drugs November 22, 2020 DOI: 10.1080/02791072.2020.1849879 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Male adult with OCD |
| Intervention | Psilocybin-containing mushrooms |
| Topics | Psilocybin |
| Keywords | Hallucinogen Obsessive compulsive Psychoactive substance |
| Citations | 34 |
| Key findings | A male adult with OCD showed a clinically meaningful reduction in OCD symptoms after consuming psilocybin-containing mushrooms. |
Abstract
Obsessive Compulsive Disorder (OCD) is a chronic neuropsychiatric condition, characterized by obsessions and compulsions, which is usually disabling for the suffering individual. The first-line treatment is not effective in all patients. There is evidence showing the effectiveness of psilocybin and psilocybin-containing mushrooms in the treatment of OCD symptoms. We present the case of a male adult with OCD who showed a clinically meaningful reduction of his OCD symptomatology after the consumption of psilocybin-containing mushrooms. Future research will determine if psilocybin and other psychoactive compounds of psilocybin-containing mushrooms are effective and safe for the treatment of OCD.
Comparable studies
Other case reports and case series on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin Mushroom (Psilocybe semilanceata) Intoxication with Myocardial Infarction 18-year-old man | 1998 | Case study | n = 1 |
| Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback (MVF) Person with leg amputation and phantom-limb pain | 2018 | Case study | n = 1 |
| Hallucinogen persisting perception disorder after psilocybin consumption: a case study 18-year-old man with HPPD after mixed psilocybin and cannabis intoxication | 2005 | Case study | n = 1 |
| Microdosing psilocybin for chronic pain: a case series Individuals with chronic neuropathic pain | 2022 | Case series | n = 3 |
| Psilocybin and Obsessive Compulsive Disorder Individual with Obsessive Compulsive Disorder | 2014 | Case study | n = 1 |
Citations in the library
Cited by 25
- Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational Psychiatry May 10, 2023
- Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats. Molecular Psychiatry September 1, 2023
- Psychotherapy with Psilocybin for Depression: Systematic Review Behavioral Sciences March 31, 2023
- A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond Biotechnology Advances August 31, 2023
- Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report Heliyon December 1, 2022
and 20 more in the library
Cites 5
- Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder The Journal of Clinical Psychiatry November 15, 2006
- Psychedelics as Medicines: An Emerging New Paradigm Clinical Pharmacology & Therapeutics November 4, 2016
- Clinical potential of psilocybin as a treatment for mental health conditions Mental Health Clinician 2017
- Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice Bioscience Biotechnology and Biochemistry August 23, 2009
- Psilocybin and Obsessive Compulsive Disorder Journal of Psychoactive Drugs October 20, 2014