Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice
Yoshihiro Matsushima, Osamu Shirota, Ruri Kikura-Hanajiri, Yukihiro Goda, Fumio Eguchi
Bioscience Biotechnology and Biochemistry August 23, 2009 DOI: 10.1271/bbb.90095 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Psilocybe argentipes psilocybin |
| Topics | Psilocybin |
| Keywords | Obsessive compulsive Animal model Hallucinogen Pharmacology |
| Citations | 77 |
| Key points | Psilocybe argentipes significantly inhibited marble-burying behavior without affecting locomotor activity, suggesting potential efficacy in obsessive-compulsive disorder therapy. |
Abstract
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.