Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice
Yoshihiro Matsushima, Osamu Shirota, Ruri Kikura-Hanajiri, Yukihiro Goda, Fumio Eguchi
Bioscience Biotechnology and Biochemistry August 23, 2009 DOI: 10.1271/bbb.90095 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Psilocybe argentipes psilocybin |
| Topics | Psilocybin |
| Keywords | Obsessive compulsive Animal model Hallucinogen Pharmacology |
| Citations | 77 |
| Key points | Psilocybe argentipes significantly inhibited marble-burying behavior without affecting locomotor activity, suggesting potential efficacy in obsessive-compulsive disorder therapy. |
Abstract
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.
Comparable studies
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| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice Mice | 2021 | Experimental study | |
| Psychedelics reopen the social reward learning critical period Mice | 2023 | Experimental study in mice | |
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Mice | 2013 | Experimental study |
Citations in the library
Cited by 59
- Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years Therapeutic Advances in Psychopharmacology March 18, 2016
- Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences? Journal of Psychopharmacology February 9, 2015
- The Therapeutic Potential of Psilocybin Molecules May 15, 2021
- Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies Brazilian Journal of Psychiatry March 1, 2016
- Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS Drugs April 1, 2013
and 54 more in the library
Cites 7
- Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder The Journal of Clinical Psychiatry November 15, 2006
- Concise Large-Scale Synthesis of Psilocin and Psilocybin, Principal Hallucinogenic Constituents of “Magic Mushroom” Journal of Natural Products May 30, 2003
- SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist Bioorganic & Medicinal Chemistry Letters August 3, 2005
- Aeruginascin, a Trimethylammonium Analogue of Psilocybin from the Hallucinogenic MushroomInocybe aeruginascens Planta Medica April 1, 2006
- Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron February 1, 2007
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