The Problem of Psilocybin Mushroom Abuse
Norman R. Peden, Stuart D. Pringle, James Crooks
Human Toxicology October 1, 1982 DOI: 10.1177/096032718200100408 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 44 |
| Population | Patients presenting to hospital after ingesting psilocybin-containing mushrooms |
| Duration | 5-week period during an outbreak |
| Topics | Psilocybin |
| Keywords | Nausea Vomiting Mushroom poisoning Hallucinogen Mydriasis Ingestion Anesthesia Amnesia Tachycardia |
| Citations | 45 |
| Key findings | The effects of psilocybin-containing mushrooms were short-lived, resolving within 12 hours in all but one patient, and inducing emesis did not hasten recovery. |
Abstract
1 We have reviewed the clinical features and management of 44 consecutive patients presenting to hospital over a 5 week period during an outbreak of ingestion of psilocybin containing mushrooms. 2 Patients presented to hospital usually because of dysphoric effects an average of 3.8 h after ingesting the mushrooms. 3 Mydriasis was present in 40 patients but fewer than half showed other sympathomimetic features - tachycardia, hypertension or hyperreflexia. 4 Twenty-three patients experienced nausea and vomiting. 5 Distortions of perception chiefly visual were frequent as were paraesthesiae and feelings of depersonalization. 6 The effects of the mushrooms were short-lived and had worn off within 12 h in all but one patient. 7 Inducing emesis did not appear to hasten recovery from the effects of the mushrooms.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |
Citations in the library
Cited by 23
- The Therapeutic Potential of Psilocybin Molecules May 15, 2021
- DARK Classics in Chemical Neuroscience: Psilocybin ACS Chemical Neuroscience June 29, 2018
- Toward a Comparative Overview of Dependence Potential and Acute Toxicity of Psychoactive Substances Used Nonmedically The American Journal of Drug and Alcohol Abuse 1993
- Investigation of the Structure–Activity Relationships of Psilocybin Analogues ACS Pharmacology & Translational Science December 14, 2020
- Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development. Fungal biology April 1, 2022
and 18 more in the library
Cites 7
- Clinical toxicology of ‘magic mushroom’ ingestion Postgraduate Medical Journal September 1, 1981
- Abuse of Indigenous Psilocybin Mushrooms: A New Fashion and Some Psychiatric Complications The British Journal of Psychiatry June 1, 1978
- COMPARISON OF THREE PSYCHOTROPIC DRUGS (PSILOCYBIN, JB-329, AND IT-290) IN VOLUNTEER SUBJECTS The Journal of Nervous and Mental Disease November 1, 1960
- SOME LESS FAMILIAR DRUGS OF ABUSE The Medical Journal of Australia November 1, 1971
- The Psilocybin Mushroom Pandemic Journal of Psychedelic Drugs 1975
and 2 more in the library