Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development.
R C Van Court, M S Wiseman, K W Meyer, D J Ballhorn, K R Amses, Jason C. Slot, Bryn T. M. Dentinger, R Garibay-Orijel, J K Uehling
Fungal biology April 1, 2022 DOI: 10.1016/j.funbio.2022.01.003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Citations | 92 |
| Key findings | Psilocybin-producing fungi, especially from the genus Psilocybe, have a long history of traditional use and are now being studied for therapeutic applications, but more mycological research is needed to ensure consumer safety. |
Abstract
Therapeutic use of psilocybin has become a focus of recent international research, with preliminary data showing promise to address a range of treatment-resistant mental health conditions. However, use of psilocybin as a healing entheogen has a long history through traditional consumption of mushrooms from the genus Psilocybe. The forthcoming adoption of new psilocybin-assisted therapeutic practices necessitates identification of preferred sources of psilocybin; consequently, comprehensive understanding of psilocybin-containing fungi is fundamental to consumer safety. Here we examine psilocybin producing fungi, discuss their biology, diversity, and ethnomycological uses. We also review recent work focused on elucidation of psilocybin biosynthetic production pathways, especially those from the genus Psilocybe, and their evolutionary history. Current research on psilocybin therapies is discussed, and recommendations for necessary future mycological research are outlined.