What Predicts Beneficial Outcomes in Psychedelic Use? A Quantitative Content Analysis of Psychedelic Health Outcomes.
Elias C Acevedo, Scott Uhler, Kaitlyn P White, Laith Al-Shawaf
Journal of Psychoactive Drugs 2025 DOI: 10.1080/02791072.2024.2314729 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Quantitative content analysis Peer reviewed |
|---|---|
| Sample size | 240 |
| Population | Psychedelic users who submitted self-reports to Erowid.org |
| Topics | Ego dissolution Mystical experience |
| Keywords | Predictive processing Psychedelics Psychological insight Therapeutic intent |
| Citations | 15 |
| Key points | Psychological insight, not metaphysical beliefs, uniquely predicted beneficial outcomes from psychedelic experiences. |
Abstract
Interest in psychedelics and their possible therapeutic potential has been growing. Metaphysical belief theory asserts that these benefits stem from the adoption of comforting supernatural beliefs following a mystical experience. By contrast, predictive self-binding theory suggests that the beneficial outcomes of psychedelics are primarily driven by psychological insights. The present study tests these competing models of psychedelic benefits. We conducted a quantitative content analysis on unsolicited self-reports of psychedelic users available on Erowid.org, to examine the potential relations between psychological insight, ego dissolution, therapeutic intent, altered metaphysical belief, and enduring health outcomes. We randomly selected, coded, and analyzed two hundred forty psychedelic experience reports from the website. Path analysis using structural equation modeling showed that psychological insight, not metaphysical beliefs, uniquely predicted beneficial outcomes. Moreover, beneficial outcomes' positive relation to ego dissolution and therapeutic intent was fully mediated by psychological insight. These findings support the predictive self-binding model over the metaphysical belief model.
Citations in the library
Cited by 15
- Investigating the relationship between changes in metaphysical beliefs and death anxiety following a significant psychedelic experience. Death Studies 2025
- Psilocybin in pharmacotherapy of obsessive-compulsive disorder Pharmacological Reports August 1, 2024
- Perceived Impact of Psychedelics on Sexual, Gender, and Intimate Relationship Dynamics: A Mixed-Methods Investigation The Journal of Sex Research March 28, 2025
- Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories. Progress in Neuro-Psychopharmacology and Biological Psychiatry April 2, 2025
- Therapeutic benefit versus epistemic risk: Need for empirical research in psychedelic epistemology. Journal of Psychiatric Research August 1, 2025
and 10 more in the library
Cites 29
- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics Pharmacological Reviews June 20, 2019
- Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later Journal of Psychopharmacology May 30, 2008
- Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression Frontiers in Pharmacology January 17, 2018
- Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI) Frontiers in Human Neuroscience June 14, 2016
- Predicting Responses to Psychedelics: A Prospective Study Frontiers in Pharmacology November 2, 2018
and 24 more in the library