A test of the transmethylation hypothesis in acute schizophrenic patients.
W T Carpenter, E B Fink, N Narasimhachari, H E Himwich
American Journal of Psychiatry October 1, 1975 DOI: 10.1176/ajp.132.10.1067 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case-control study Peer reviewed |
|---|---|
| Sample size | 36 |
| Population | 26 acutely schizophrenic patients and 10 normal control subjects |
| Citations | 31 |
| Key findings | Acutely schizophrenic patients were no more likely than normal controls to have bufotenine or N,N-dimethyltryptamine in urine or elevated serum indolethylamine N-methyltransferase activity. |
Abstract
Keeping biochemical determinations and clinical judgements independent, the authors investigated three aspects of the transmethylation hypothesis. They found that 26 acutely schizophrenic patients were no more likely to have bufotenine or N,N-dimethyltryptamine present in urine or elevated serum indolethylamine N-methyltransferase activity than 10 normal control subjects. The authors conclude that these are naturally occurring substances which are equally likely to be present in normal and schizophrenic subjects.
Citations in the library
Cited by 10
- A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010. Drug Testing and Analysis 2012
- The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine American Journal of Psychiatry February 1, 1976
- Altered consciousness states and endogenous psychoses: a common molecular pathway? Schizophrenia Research December 19, 1997
- Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method. Journal of Chromatography. B, Biomedical Sciences and Applications February 10, 2001
- Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans. Phytochemistry February 1, 2024
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