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Dimethyltryptamine levels in blood of schizophrenic patients and control subjects

B. Angrist, S. Gershon, G. Sathananthan, R. W. Walker, B. Lopez-Ramos, L. R. Mandel, W. J. A. Vandenheuvel

Psychopharmacology 1976 DOI: 10.1007/bf00428697 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Observational cohort Peer reviewed
Population Normal controls and schizophrenic patients
Topics DMT 5-MeO-DMT
Keywords Blood levels Schizophrenia Assay
Citations 44
Key findings Mean DMT levels were not statistically significantly different between schizophrenic patients and controls, despite apparent elevations in certain subgroups.

Abstract

A gas chromatographic-mass spectrometric determination of blood N,N-dimethyltryptamine in normal controls and schizophrenic patients was carried out with a sensitivity limit of 0.05 ng/ml whole blood. Although the results appear to suggest that the mean DMT level was higher in the total patient group, those patients with acute psychosis, female patients and patients with suspiciousness scores on the BPRS of 4 or over, the differences were not statistically significant.

Comparable studies

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Study Year Design Participants
Neural correlates of the DMT experience assessed with multivariate EEG. 6 female, 7 male human participants 2019 Observational cohort n = 13
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Volunteers who inhaled vapor from dried toad secretion at several European locations 2019 Observational cohort n = 42
Metabolism and urinary disposition of N,N‐dimethyltryptamine after oral and smoked administration: a comparative study DMT users 2014 Observational cohort n = 6
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study Individuals at a psychospiritual retreat in Mexico 2018 Observational cohort n = 20
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings. Healthy and experienced participants 2021 Observational field study n = 35

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