Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.
Richard A Glennon, R Young, F Benington, R D Morin
Life Sciences February 1, 1982 DOI: 10.1016/0024-3205(82)90463-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-methoxy-N N-dimethyltryptamine (5-OMe DMT) |
| Dose | 1.5 mg/kg (training dose of 5-OMe DMT); challenge doses not specified |
| Topics | DMT |
| Citations | 8 |
| Key findings | The 5-OMe DMT cue generalized to the 4-methoxy, 4-methylthio, and 5-methylthio derivatives of DMT, with potency ranking 5-OMe > 5-SMe > 4-OMe > 4-SMe DMT. |
Abstract
Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all three of these agents; the order of potency is 5-OMe greater than 5-SMe greater than 4-OMe greater than 4-SMe DMT.