Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities.
Richard A Glennon, R Young, John A. Rosecrans, M J Kallman
Psychopharmacology 1980 DOI: 10.1007/BF00432133 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 24 |
| Population | Rats |
| Interventions | 5-methoxy-N N-dimethyltryptamine (5-OMe DMT) saline |
| Topics | Serotonin |
| Citations | 46 |
| Key findings | The hallucinogenic drug 5-OMe DMT's effects generalize to related tryptamine compounds in a dose-dependent manner, and the potency of these compounds correlates strongly with their affinity for serotonin receptors. |
Abstract
A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r = -0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).