Effects of ibogaine on performance in the 8-arm radial maze.
Scott Helsley, David Fiorella, R A Rabin, Jerrold C Winter
Pharmacology, Biochemistry, and Behavior September 1, 1997 DOI: 10.1016/s0091-3057(96)00476-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Rats |
| Intervention | Ibogaine |
| Dose | 50 mg/kg IP administered twice with approximately 8 h between injections; 30 mg/kg IP |
| Topics | Ibogaine |
| Citations | 9 |
| Key findings | Ibogaine did not impair acquisition or efficiency in a radial maze task but reduced response rate. |
Abstract
The effects of ibogaine were studied in 12 rats trained to perform in an 8-arm radial maze. In Phase I, the mean number of sessions to criterion and cumulative errors to criterion, as well as mean response rate, were determined for two groups of six animals in a task where only four arms were baited. Group 1 received a potentially neurotoxic dose of ibogaine (50 mg/kg IP administered twice, with approximately 8 h between injections), and group 2 received vehicle. Both groups had similar levels of performance, but ibogaine-treated subjects had a significantly lower rate of responding in the maze. During Phase II, subjects were given a range of doses of ibogaine 20 min prior to working in the maze. Ibogaine produced a dose-dependent decrease in response rate, but efficiency (% arms correct) was not affected. In Phase III, subjects were divided into the same groups as they had been in Phase I. Ibogaine (30 mg/kg, IP) or vehicle was administered immediately following daily sessions in the maze. Ibogaine-treated rats committed significantly fewer errors than those in the vehicle treated group. Thus, in the present study, ibogaine failed to produce any deleterious effects on either acquisition of a novel task or efficiency in a previously learned task.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 5
- Fatalities temporally associated with the ingestion of ibogaine. Journal of Forensic Sciences March 1, 2012
- The adverse events of ibogaine in humans: an updated systematic review of the literature (2015-2020). Psychopharmacology June 1, 2022
- Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat. Brain Research June 13, 1997
- Ibogaine and the inhibition of acetylcholinesterase. Journal of Ethnopharmacology February 15, 2012
- Ibogaine: Therapeutic Potential, Cardiac Safety, and Translational Perspectives in the Treatment of Substance Use Disorders—A Scoping Review Molecules February 4, 2026
Cites 10
- Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Neuroscience July 1, 1993
- Effects and aftereffects of ibogaine on morphine self-administration in rats. European Journal of Pharmacology April 3, 1991
- Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research September 19, 1994
- Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology September 14, 1993
- A preliminary investigation of ibogaine: case reports and recommendations for further study. Journal of Substance Abuse Treatment 1994
and 5 more in the library