Effects of low dose ibogaine on subjective mood state and psychological performance.
Bridget Forsyth, Liana Machado, Tim Jowett, Hannah Jakobi, Kira Garbe, Helen Winter, Paul Glue
Journal of Ethnopharmacology August 2, 2016 DOI: 10.1016/j.jep.2016.05.022 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preprint Double-blind Peer reviewed |
|---|---|
| Sample size | 21 |
| Population | Healthy male volunteers |
| Intervention | Ibogaine |
| Dose | 20 mg |
| Duration | Single dose, with testing before and 2 hours after dosing; 6 days pretreatment with paroxetine or placebo |
| Topics | Ibogaine |
| Keywords | Ibogaine study: ibogaine Low-dose ibogaine Single 20mg dose Researchers investigated Assessments Test this Psychological test performance Specific cognitive modulation Subjective mood rating Overall mood Stimulant Largely unaffected Subtle Limited effect |
| Citations | 35 |
| Key points | Ibogaine had minimal influence on psychological tests and mood ratings, with no stimulant effects identified after a single 20mg dose. |
Abstract
Root bark from Tabernanthe iboga has been used traditionally in West Africa as a psychoactive substance in religious rituals. In smaller doses it is reported anecdotally to have stimulant properties. To evaluate the influence of a single 20mg ibogaine dose on psychological variables reflecting subjective mood state and a range of cognitive functions. 21 healthy male volunteers received single 20mg doses of ibogaine after 6 days pretreatment with double-blind paroxetine or placebo. We compared responses to a battery of psychometric tests and subjective mood ratings performed before and 2h after ibogaine dosing, and assessed relationships between changes in test scores and concentrations of active moiety (the sum of molar noribogaine and ibogaine concentrations). Psychological tests were chosen based on responsiveness to opioid and serotonergic ligands. Ibogaine had minimal influence on psychological tests and mood ratings. The ability to selectively ignore distracting spatial information showed some evidence of modulation; however because this effect was limited to the less challenging condition calls into question the reliability of this result. We were unable to identify stimulant effects after single 20mg doses of ibogaine. Future research is needed to confirm whether active moiety concentrations impact selective attention abilities while leaving other cognitive functions and mood state unaffected.