Effects of ibogaine on responding maintained by food, cocaine and heroin reinforcement in rats.
S I Dworkin, S Gleeson, D Meloni, T R Koves, T J Martin
Psychopharmacology February 1, 1995 DOI: 10.1007/bf02246099 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Ibogaine |
| Dose | 40 and 80 mg/kg, i.p. |
| Duration | Single session with pretreatment times of 60 or 90 minutes, and follow-up for 48 hours |
| Topics | Ibogaine |
| Citations | 49 |
| Key findings | Ibogaine dose-dependently suppressed operant responding for food, cocaine, and heroin in rats, with heroin-maintained behavior being the most sensitive and showing rapid recovery. |
Abstract
The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in a 97% decrease in the number of ratios completed under the food reinforcement schedule and resulted in a decrease in responding the following day. Neither 40 mg/kg ibogaine given 60 min prior to the session nor 80 mg/kg given 24 h before the session suppressed responding maintained by cocaine infusions (0.33 mg/infusion). Pretreatment with 80 mg/kg ibogaine either 60 or 90 min prior to the session suppressed cocaine self-administration on the day it was administered and the longer pretreatment continued to suppress responding for 48 h. Responding maintained by heroin (18 micrograms/infusion) was the most sensitive to the effects of ibogaine. Both 40 and 80 mg/kg ibogaine resulted in an almost complete suppression of responding following a 60-min pretreatment period. Responding maintained by heroin returned to control levels the day following the administration of ibogaine.