Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat.
Scott Helsley, C A Dlugos, R J Pentney, R A Rabin, Jerrold C Winter
Brain Research June 13, 1997 DOI: 10.1016/s0006-8993(97)00365-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Male Fischer 344 rats |
| Intervention | Ibogaine |
| Dose | 10 mg/kg |
| Duration | 60-day intervention |
| Topics | Ibogaine |
| Citations | 19 |
| Key findings | Chronic ibogaine administration did not significantly reduce cerebellar Purkinje cell number in male Fischer 344 rats. |
Abstract
The present investigation assessed the chronic toxicity of ibogaine on cerebellar Purkinje cells in male Fischer 344 rats. A behaviorally active dose of ibogaine (10 mg/kg, i.p.) was administered to a group of six subjects every other day for 60 days while the control group received an equivalent volume of saline (1 ml/kg). Estimates of Purkinje cell number were determined using the optical dissector/fractionator technique. No significant differences in Purkinje cell number were observed between the ibogaine (243764[+/-32766]) and control groups (230813[+/-16670]).