2C-B: a new psychoactive phenylethylamine recently discovered in Ecstasy tablets sold on the Swiss black market.
Christian Giroud, Marc Augsburger, L Rivier, Patrice Mangin, F Sadeghipour, E Varesio, J L Veuthey, P Kamalaprija
Journal of Analytical Toxicology September 1, 1998 DOI: 10.1093/jat/22.5.345 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Analytical study Peer reviewed |
|---|---|
| Population | Two sets of tablets from the Swiss black market |
| Topics | MDMA |
| Keywords | 2c-b Drug identification Illicit drugs Drug dosage |
| Citations | 57 |
| Key points | 2C-B was identified in tablets from the Swiss black market at doses of 3-8 mg, within the range needed for psychoactive effects. |
Abstract
This study sought to identify, by means of several analytical methods (GC-MS, HPLC-DAD, CE-DAD, FTIR, and NMR), 4-bromo-2,5-dimethoxyphenethylamine (2C-B), which was found in two sets of tablets obtained from the Swiss black market. Unequivocal identification of 2C-B was only achieved by a combination of mass spectrometric and NMR analysis. Quantitation of 2C-B was performed by HPLC-DAD and CE-DAD. The amounts of 2C-B found in the tablets (3-8 mg) were in the range of the minimum quantity required to induce the effects characteristic of this drug.
Citations in the library
Cited by 18
- 4-Bromo-2,5-dimethoxyphenethylamine (2C-B): presence in the recreational drug market in Spain, pattern of use and subjective effects. Journal of Psychopharmacology July 1, 2012
- Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. Toxicology January 5, 2005
- Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose Psychopharmacology October 6, 2007
- 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes. British Journal of Pharmacology April 1, 2004
- Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans. Drug and Alcohol Dependence December 1, 2015
and 13 more in the library
Cites 4
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- Alpha-adrenergic and 5-HT2-serotonergic effects of some beta-phenylethylamines on isolated rat thoracic aorta. General pharmacology 1994
- A behavioral comparison of Nexus, cathinone, BDB, and MDA. Pharmacology, Biochemistry, and Behavior 1995
- A preliminary investigation of the psychoactive agent 4-bromo-2,5-dimethoxyphenethylamine: a potential drug of abuse. Pharmacology, Biochemistry, and Behavior July 1988