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Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions

Débora González, Marta Torrens, Magı́ Farré

BioMed Research International 2015 DOI: 10.1155/2015/643878 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Observational cohort Peer reviewed
Sample size 20
Population Healthy recreational 2C-B users (12 women)
Intervention 2C-B
Dose 20 mg
Topics MDMA
Keywords Hallucinogen Euphoriant Happiness Anger Heart rate Stimulant Recreational drug Blood pressure
Citations 44
Key findings 2C-B reduced anger but increased reactivity to negative emotional stimuli and decreased recognition of happiness, supporting its classification as an entactogen with psychedelic properties.

Abstract

Background . 2C-B (Nexus) is one of the most widespread novel psychoactive substances. There is limited information about its pharmacological properties, and few studies in humans concern its acute and chronic effects. 2C-B has been classified as a stimulant, hallucinogen, entactogen, and/or empathogen. Objectives . To evaluate the emotional, subjective, and cardiovascular effects of 2C-B. Methods . Twenty healthy recreational 2C-B users (12 women) self-administered a 20 mg dose of 2C-B. Evaluations included emotional (IAPS, FERT, and speech), subjective (visual analog scales, ARCI, VESSPA, HRS, and POMS questionnaires), and cardiovascular effects (blood pressure and heart rate). Results . Positive subjective effects predominated with a reduction of anger under the influence of 2C-B. It did, however, increase reactivity to negative emotional stimuli and decrease the ability to recognize expressions of happiness. Augmented emotionality in speech could be appreciated by others. 2C-B induced euphoria and well-being, changes in perceptions, and slight hallucinogenic states. Mild sympathetic actions were observed. Conclusions . The specific profile that 2C-B exerts on emotions suggests its classification as an entactogen with psychedelic properties.

Comparable studies

Other observational and cohort studies on MDMA, most cited first.

Study Year Design Participants
Subjective Reports of the Effects of MDMA in a Clinical Setting Individuals who took MDMA in a clinical setting 1986 Observational study
Memory impairment in abstinent MDMA ("Ecstasy") users Abstinent MDMA users 1998 Observational cohort
Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people 2000 Observational
The Psychological and Physiological Effects of MDMA on Normal Volunteers Older, more educated, drug-experienced individuals 1986 Observational cohort
Cognitive performance in recreational users of MDMA or 'ecstasy': evidence for memory deficits Young people who were regular or novice MDMA users, or non-users 1998 Observational cohort n = 30

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