D O De Souza

Long-lasting ibogaine protection against NMDA-induced convulsions in mice.

Neurochemical Research August 1, 2000 M B Leal, D O De Souza, E Elisabetsky 23 citations

Ibogaine, a putative antiaddictive drug, is remarkable in its apparent ability to downgrade withdrawal symptoms and drug craving for extended periods of time after a single dose. Ibogaine acts as a non-competitive NMDA receptor antagonist, while NMDA has been implicated in long lasting changes in neuronal function and in the physiological basis of drug addiction. The purpose of this study was...