Potential Serotonin 5-HT2A Receptor Agonist of Psychoactive Components of Silene undulata Aiton: LC-MS/MS, ADMET, and Molecular Docking Studies.
Current Pharmaceutical Biotechnology January 1, 2025 Maram B Alhawarri, Suleiman Olimat 10 citations
An extract of the plant Silene undulata, traditionally used to induce vivid dreams, contains 51 phytochemicals including the β-carboline alkaloids norharman, harmalol, harmaline, harmine, and ibogaine. Computer simulations predicted that harmaline, harmalol, and ibogaine bind to the serotonin 5-HT2A receptor with affinities comparable to LSD, suggesting they may act as agonists. The compounds also showed favorable predicted pharmacokinetic properties. These results support the plant's historical psychoactive use and point to potential therapeutic applications, though further research is needed.