Psilocybin decreases neural responsiveness and increases functional connectivity while preserving pure-tone frequency selectivity in mouse auditory cortex
Adam T. Brockett, Nikolas A. Francis
Journal of Neurophysiology May 29, 2024 DOI: 10.1152/jn.00124.2024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Awake mice |
| Intervention | Psilocybin |
| Topics | Psilocybin |
| Keywords | Psychedelics hallucinogens Hearing Auditory cortex Behavior Neuroscience brain research Brain function Entheogens Neural activity |
| Citations | 8 |
| Key findings | Psilocybin modulates the relative roles of intrinsic neural activity and stimulus-driven influences on auditory processing in the auditory cortex. |
Abstract
Recent studies have shown promising therapeutic potential for psychedelics in treating neuropsychiatric conditions. Musical experience during psilocybin-assisted therapy is predictive of treatment outcome, yet little is known about how psilocybin affects auditory processing. Here, we conducted two-photon imaging experiments in auditory cortex of awake mice that received a dose of psilocybin. Our results suggest that psilocybin modulates the roles of intrinsic neural activity versus stimulus-driven influences on auditory perception.