Bioanalysis
July 1, 2016
Cláudia Margalho, Francisco Corte Real, Manuel López-rivadulla et al.
The identification and quantitation of the main psychoactive component of Salvia divinorum (salvinorin A) in biological specimens are crucial in forensic and clinical toxicology. Despite all the efforts made, its uncontrolled abuse has increased quickly, exposing its users' health to serious risks both in the short and long term. The use of alternative biological matrices in toxicological...
Bioanalysis
July 1, 2012
Carolina Dizioli Rodrigues de Oliveira, Guilherme Gonçalves Okai, José Luiz Costa et al.
33 citations
The method proved to be simple, rapid and useful to estimate administered doses for further pharmacological and toxicological investigations of ayahuasca exposure.
Bioanalysis
March 1, 2010
Graham Lappin
36 citations
The concept of microdosing has been around for approximately 10 years. In this time there have been an increasing number of drugs reported in the literature where the pharmacokinetics at a microdose have been compared with those observed at a therapeutic dose. Currently, approximately 80% of the microdose pharmacokinetics available in the public domain have been shown to scale to those observed...
Bioanalysis
March 1, 2010
Welcome to 'microdosing'.
Bioanalysis
March 1, 2010
Opinion: Microdosing: safer clinical trials and fewer animal tests.
Bioanalysis
March 1, 2010
P. Henderson, C. Pan
Microdosing allows study of the behavior of drugs via the administration of doses so low they are unlikely to produce whole-body effects, but of sufficient concentration to allow the determination of absorption, distribution, metabolism and excretion (ADME). Microdosing was recently reviewed elsewhere [1,2]; although most effort to date has focused on pharmacokinetic (PK) predictions to...
Bioanalysis
March 1, 2010
Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development.
Bioanalysis
March 2010
A P Jekunen, E K J Pauwels, K J A Kairemo
Microdosing provides a tool to enhance drug development by initiating human studies prior to Phase I studies. The purpose is to assist in the go versus no-go decision-making process and to eliminate early ineffective compounds from the drug pipeline. Selection of multiple potential leads can be performed at the clinical stage instead of in preclinical studies. The microdosing approach can be...
Bioanalysis
June 11, 2009
G. Lappin, C. Wagner, O. Langer et al.
In a microdosing study, subpharmacologically active doses of drug are given to human volunteers at an early stage of development in order to obtain preliminary pharmacokinetic data. The very low doses of drug administered (≤100 µg) consequently lead to very low concentrations of drug appearing in the body and therefore highly sensitive analytical techniques are required. There are three such...
Bioanalysis
March 27, 2009
Hong-Wu Shen, Xi-Ling Jiang, Ai-Ming Yu
26 citations
INTRODUCTION: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychoactive indolealkylamine substance that has been used for recreational purpose and may lead to fatal toxicity. While 5-MeO-DMT is mainly inactivated via deamination, it is O-demethylated to an active metabolite, bufotenine. Quantitation of 5-MeO-DMT and bufotenine is essential to understand the exposure to and the effects of...