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RSC Advances

ISSN 2046-2069

2 papers in the library · 13 citations · publishing 2017-2018

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Use of novel haptens in the production of antibodies for the detection of tryptamines.

RSC Advances April 27, 2018 Michal Maryška, Lucie Fojtíková, Radek Jurok et al.

Tryptamines are a group of hallucinogenic drugs whose detection in body fluids could be simplified by immunochemical assay kits. Antibodies for these assays are obtained by the immunization of laboratory animals with conjugates of a hapten similar to the target analyte and a suitable protein. Therefore we synthesized novel haptens derived from tryptamine-based drugs, with N,N-dimethyltryptamine...

Synthesis of methoxetamine, its metabolites and deuterium labelled analog as analytical standards and their HPLC and chiral capillary electrophoresis separation

RSC Advances 2017 Bronislav Jurásek, Michal Himl, Radek Jurok et al. 13 citations

Methoxetamine, a designer drug marketed as a replacement for the dissociative anaesthetic ketamine, has been associated with significant numbers of hospital related intoxications and deaths in Europe.