ISSN 0006-8950; 1460-2156;
14 papers in the library · 2,169 citations · publishing 2004-2026
Brain May 15, 2026 Boris B. Quednow, Rebecca C Coray
Boris B Quednow, Rebecca C Coray; Reply: The consequences of MDMA use are not easily disentangled from other drug use or lifestyle factors, Brain, , awag17
Brain April 30, 2026 Lukas A Basedow
The consequences of MDMA use are not easily disentangled from other drug use or lifestyle factors.
Brain December 12, 2025 Robin Carhart-Harris 2 citations
Introduced in 2014 and revised in 2018, the entropic brain hypothesis has accrued a wealth of supportive evidence. The hypothesis states that-along a dimension of the size of phenomenal consciousness-expansive states reliably exhibit increased brain entropy whereas the inverse applies for states of no or reduced consciousness. Examples of expansive states include expert meditation, flicker...
Brain October 19, 2025 Rebecca C Coray, Vincent Beliveau, Josua Zimmermann et al. 1 citation
Regular recreational use of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") has been consistently linked to verbal memory dysfunctions, whose neurobiological origins remain unclear. Although neurochemical, structural, and functional alterations resulting from repeated MDMA intake have been identified in user populations, only limited knowledge exists regarding potential interrelationships...
Brain May 4, 2024 Jérôme Jeanblanc, Romain Bordy, Grégory Fouquet et al. 10 citations
Abstract The use of psilocybin to treat alcohol use disorder is very promising, but its mechanisms of action remain poorly understood. We combined behavioural, pharmacological and gene expression analyses to decipher the mechanisms of action of psilocybin, for the first time, when injected into the brain. Male Long Evans rats underwent chronic operant ethanol self-administration before testing...
Brain 2024 Andrea I. Luppi, Manesh Girn, Fernando E. Rosas et al. 25 citations
Integrating independent but converging lines of research on brain function and neurodevelopment across scales, this article proposes that serotonin 2A receptor (5-HT2AR) signalling is an evolutionary and developmental driver and potent modulator of the macroscale functional organization of the human cerebral cortex. A wealth of evidence indicates that the anatomical and functional organization...
Brain October 22, 2021 Manoj K. Doss, Maxwell B. Madden, Andrew Gaddis et al. 196 citations
Abstract Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have recaptured the imagination of both science and popular culture, and may have efficacy in treating a wide range of psychiatric disorders. Human and animal studies of psychedelic drug action in the brain have demonstrated the involvement of the serotonin 2A (5-HT2A) receptor and the cerebral cortex in...
Brain March 6, 2021 Joel Frohlich, Daniel Toker, Martin M. Monti 204 citations
Abstract A common observation in EEG research is that consciousness vanishes with the appearance of delta (1–4 Hz) waves, particularly when those waves are high amplitude. High amplitude delta oscillations are frequently observed in states of diminished consciousness, including slow wave sleep, anaesthesia, generalized epileptic seizures, and disorders of consciousness, such as coma and the...
Brain October 24, 2017 Matt Ffytche, Dominic H Ffytche
What does an eminent neuroanatomist dream of at night? The panic of being an auxiliary professor and receiving last minute instructions from the Dean to lecture on osteology? ‘Anxiety, distress … upon reviewing the bones in my memory. I list those of the hand: scaphoids, capitate, and I did not know any more’; or perhaps of secretly cutting slices of medulla for staining in a boarding house at...
Brain April 9, 2013 Winston Chiong, Stephen M. Wilson, Mark D’Esposito et al. 234 citations
Large-scale brain networks are integral to the coordination of human behaviour, and their anatomy provides insights into the clinical presentation and progression of neurodegenerative illnesses such as Alzheimer's disease, which targets the default mode network, and behavioural variant frontotemporal dementia, which targets a more anterior salience network. Although the default mode network is...
Brain May 17, 2010 Stephen J. Kish, Jason P. Lerch, Yoshiaki Furukawa et al. 170 citations
Animal data indicate that the recreational drug ecstasy (3,4-methylenedioxymethamphetamine) can damage brain serotonin neurons. However, human neuroimaging measurements of serotonin transporter binding, a serotonin neuron marker, remain contradictory, especially regarding brain areas affected; and the possibility that structural brain differences might account for serotonin transporter binding...
Brain February 28, 2010 R. L. Carhart-Harris, K. J. Friston 580 citations
This article explores the notion that Freudian constructs may have neurobiological substrates. Specifically, we propose that Freud's descriptions of the primary and secondary processes are consistent with self-organized activity in hierarchical cortical systems and that his descriptions of the ego are consistent with the functions of the default-mode and its reciprocal exchanges with...
Brain February 4, 2010 Marc Jeannerod 1 citation
What is it like to be conscious? Whereas nobody knows, by definition, what is it like to be unconscious, everybody knows what is it like to be conscious. Those of our mental states that are conscious have a distinctive phenomenal character, which we can experience and report. For example, there is something about seeing things that has its own distinctive character, which differs from hearing...
Brain January 15, 2004 Olaf Blanke, Théodor Landis, Laurent Spinelli et al. 746 citations
During an out-of-body experience (OBE), the experient seems to be awake and to see his body and the world from a location outside the physical body. A closely related experience is autoscopy (AS), which is characterized by the experience of seeing one's body in extrapersonal space. Yet, despite great public interest and many case studies, systematic neurological studies of OBE and AS are...